Current Trends in Biomedical Sciences (BIOC 5106)

Scientific literature-based course covering diverse themes in biomedical sciences.  Small group, highly-interactive format involves advanced topics, including how sophisticated experimental technologies are used to define the underlying biology, etiology and treatment of human diseases.  (3 credit hours, spring)

Biochemical Methods (BIOC 5109)

Focuses on the application of biochemistry and molecular biology concepts to quantitative measurements in biological systems. Includes the principles of separation science, electrochemistry, enzyme and metabolic kinetics, spectroscopy, radiochemistry, and immunochemistry. Emphasis is placed on experimental design and data interpretation. (3 credit hours, spring)

Biology of Cancer (BIOC 6103)

Molecular and cellular aspects of cancer biology with special emphasis on the acquired capabilities of cancer cells and how this information as translated into innovative treatment strategies. Prerequisites: successful completion of first-year core graduate courses or consent of course director. (2 credit hours, spring of even numbered years)

Special Topics in Proteomics (BIOC 6102)

The course will cover the fundamentals of mass spectrometry, including both instrument design and applications. The course will focus in depth on how mass spectrometry is used to identify proteins and post-translational modifications, and will cover quantification of proteins by isotopic labeling and label-free methods. Sample preparation and experimental design considerations important in optimizing the quality of mass spectrometric data will be covered. The course will focus extensively on current software and methods for analyzing large proteomic data sets. (2 credit hours, spring of even numbered years)

Special Topics in Proteins, Enzymes, and Molecular Machines (BIOC 6102)

The primary goal of the course is to provide understanding of physical laws underlying biological phenomena. Specifically, the course will examine physical laws behind molecular structure, function, and enzyme kinetics. For example, Michaelis-Menten equation will be revisited and derived from first principles. Similarly, from first principles, concepts of biological system and biological information processing will be presented. How is it possible, that macromolecular machinery of the cells functions with high precision and fidelity, at room temperature, amidst all the chaos of unstoppable thermal noise? This question will be answered throughout the course by tapping into systems science, irreversible thermodynamics, membrane structure, macromolecular dynamics, folding, aggregation, and other topics of contemporary biophysics. Overview of single-molecule experimental methods to study enzymes and molecular machines will be presented.