May 20, 2020

Cancer Institute Member Spotlight

Samuel Mackintosh, Ph.D.

Assistant Professor
Department of Biochemistry and Molecular Biology
UAMS College of Medicine
Co-Director, Winthrop P. Rockefeller Cancer Institute Proteomics Shared Resource and UAMS Proteomics Core Facility

Research Interest Statement

My research interests are focused on proteomics and mass spectrometry. As co-director of the Proteomics Shared Resource and UAMS Proteomics Core Facility, I am involved in a wide variety of basic and translational research projects and collaborations at any given time. The core facility maintains and operates five state-of-the-art mass spectrometers, two of which I secured for the facility with NIH shared instrument grants. The core lab offers cutting-edge, affordable proteomics analysis to all UAMS investigators and Cancer Institute members. Our facility is nationally recognized with users in 35 states and Puerto Rico, and our research is routinely published in high-impact, peer-reviewed journals. We work closely with other researchers to help them design proteomics experiments, apply for grants and publish papers. We offer complete sample processing services so that our collaborators can submit samples they can easily prepare in their own labs. We also work closely with the UAMS Bioinformatics Core to prepare data for our collaborators in publication-ready formats.

Dr. Mackintosh’s Cancer–related Grants

NIH/NIGMS: 1S10OD026736

Samuel Mackintosh: Project PI

Title “Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer”

08/01/2019 to 07/31/2020

$763,961*

*project direct cost

As part of Dr. Mackintosh’s role as co-director of the Winthrop P. Rockefeller Cancer Institute Proteomics Shared Resource and UAMS Proteomics Core Facility, he also serves as Co-I on the ACRI/UAMS COBRE grant (Center for Translational Pediatric Research, PI: Alan Tackett PhD., NIH award P20GM121293) and the UAMS INBRE grant (Partnerships for Biomedical Research in Arkansas, PI: Larry Cornett PhD., NIH award P20GM103429).

Dr. Mackintosh’s UAMS Collaborators

College of Medicine

Department of Internal Medicine

John Arthur, M.D., Ph.D.

Jawahar Mehta, M.D., Ph.D.

 

Department of Geriatrics

Srinivas Ayyadevara, Ph.D.

Richard Dennis, Ph.D.

Robert Reis, Ph.D.

 

Department of Biochemistry and Molecular Biology

Giulia Baldini, Ph.D.

Marie Burdine, Ph.D.

Alicia Byrd, Ph.D.

Stephanie Byrum, Ph.D.

Tim Chambers, Ph.D.

Rick Edmondson, Ph.D.

Robert Eoff, Ph.D.

Samantha Kendrick, Ph.D.

Grover Miller, Ph.D.

Kevin Raney, Ph.D.

Aaron Storey, Ph.D.

Alan Tackett, Ph.D.

Wayne Wahls, Ph.D.

Boris Zybaylov, Ph.D.

 

Department of Neurobiology and Developmental Sciences

Edgar Garcia-Rill, Ph.D.

Angus MacNicol, Ph.D.

 

Department of Biochemistry and Molecular Biology

Renny Lan, Ph.D.

 

Department of Pathology

Mayumi Nakagawa, M.D., Ph.D.

Steven Post, Ph.D.

 

Department of Physiology and Biophysics

Roy Morello, Ph.D.

 

Department of Microbiology and Immunology

Mark Smeltzer, Ph.D.

 

College of Pharmacy

Department of Pharmaceutical Sciences

Martin Hauer-Jensen, M.D., Ph.D.

 

College of Public Health

Department of Environmental and Occupational Health

Mitch McGill, Ph.D.

Gunnar Boysen, Ph.D.

 

Dr. Mackintosh’s External Collaborators

Randy Haun, Ph.D., Arkana Laboratories

Jeffrey Lewis, Ph.D., UA-Fayetteville

Arthur Salomon, Ph.D., Brown University

Sean Taverna, Ph.D., Johns Hopkins University

Greg Wang, Ph.D., University of North Carolina

Michael Wang, M.D., MD Anderson Cancer Center

Michael Washburn, Ph.D., Stowers Institute for Medical Research

Andrew Xiao, Ph.D., Yale University

Qin Yan, Ph.D., Yale University

Daohong Zhou, M.D., University of Florida

 

Opportunities for Collaboration

The resources of the Proteomics Core are available to anyone at UAMS, and there are pilot funding opportunities available for Cancer Institute members.