Instructor

Ph.D., University of Colorado, Health Sciences CenterIMG_2880
B.S., University of Denver

E-mail:  MareckiJohnC@uams.edu
Lab:  (501)686-7254 – Biomedical Research Center 2 421-2
FAX:  (501) 686-8169

 

Oxidative Stress Biology

My work in the Raney laboratory concerns the role of reactive oxygen species as a consequence of metabolism, as well as signaling molecules in the cell under pathophysiological conditions. With an excess of oxidative species, known as oxidative stress, damage may occur to membranes, proteins and DNA contributing to disease. In the Raney laboratory, we investigate the oxidative stress-induced cellular pathways of DNA repair for particular genomic DNA structures known as quadruplex DNA (G4 DNA) as a potential propagator of stress signaling in cells. We utilize cell culture, confocal microscopy and bioanalytical techniques to investigate links between DNA damage, repair and oxidative stress.

 

Byrd AK, Zybailov BL, Maddukuri L, Gao J, Marecki JC, Jaiswal M, Bell MR, Griffin WC, Reed MR, Chib S, Mackintosh SG, MacNicol AM, Baldini G, Eoff RL, Raney KD. (2016) “Evidence that G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.” J Biol Chem. Jul 1. pii: jbc.M116.718478. [Epub ahead of print] PMID: 27369081 [Abstract]

Marecki JC, Parajuli N, Crow JP, MacMillan-Crow LA. (2014) “The use of the Cre/loxP system to study oxidative stress in tissue-specific manganese superoxide dismutase knockout models.” Antioxid Redox Signal. 20(10):1655-70. PMID: 23641945 [Abstract]

Crow JP, Marecki JC, Thompson M. (2012) “D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology.” Neurol Res Int.625245. PMID: 23029613 [Abstract]

Thompson M, Marecki JC, Marinesco S, Labrie V, Roder JC, Barger SW, Crow JP. (2012) “Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.” J Neurochem. 120(4):598-610. PMID: 22117694 [Abstract]

Marecki JC, Ronis MJ, Shankar K, Badger TM. (2011) “Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats.” J Nutr Biochem. 22(2):142-52. PMID: 20435456 [Abstract]

Marecki JC, Cool CD, Parr JE, Beckey VE, Luciw PA, Tarantal AF, Carville A, Shannon RP, Cota-Gomez A, Tuder RM, Voelkel NF, Flores SC. (2006) “HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques.” Am J Respir Crit Care Med. 174(4):437-45. PMID: 16728715 [Abstract]

Marecki JC, Cota-Gomez A, Vaitaitis GM, Honda JR, Porntadavity S, St Clair DK, Flores SC. (2004) “HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity.” Free Radic Biol Med. 37(6):869-80. PMID: 15706661 [Abstract]

Marecki JC, McCord JM. (2002) “The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells”. Arch Biochem Biophys. 2002 Jun 15;402(2):227-34. PMID: 12051667 [Abstract]

 

Complete List of Published Work in My Bibliography