Professor and Research Subject Advocate
for the UAMS/VA General Clinical Research Center
M.D., University of Texas Health Science Center, Southwestern Medical School
Board certified in Pediatrics and Pediatric Gastroenterology
Ph.D. University of Texas Health Science Center, Southwestern Medical School
M.S., Stanford University
B.S., Baylor University
Office: (501)526-4201 – Barton 6R08A
Lab: (501)526-4201 – Barton 6R06/6R11
Areas of current Research Interest
Nutrition of Biotin- Incidence of biotin deficiency in pregnancy and potential role of biotin deficiency in human teratogenesis; biotin metabolism, particularly degradation and regulation of degradation of biotin; mechanism and regulation of cellular uptake including inborn errors of biotin transport; role of biotin in biotinylation of histones and their potential role on DNA replication or transcription.
Non-radioactive measurement of red cell mass and red cell survival.
Biotinylation of low molecular peptides hormones such as erythropoietin and subsequent quantitation in order to study pharmacokinetics of endogenously secreted erythropoietin and potentially other hormones.
Selected Publications (from a total of 139)
Widness J.A., Kuruvilla D.J., Mock D.M., Matthews N.I., Nalbant D., Cress G.A., Schmidt R.L., Strauss R.G., Zimmerman M.B., Veng-Pedersen P. Autologous Infant and Allogeneic Adult red cells demonstrate similar concurrent post-transfusion survival in very low birth weight neonates. J. Pediatr. doi: 10.1016/j.jpeds.2015.08.028, 2015. |Abstract|
Sedel F., Bernard D., Mock D.M., Toubah A. Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis Neuropharmacology 2015; doi:10.1016/j.neuropharm.2015.08.028. |Abstract|
Bogusiewicz A., G. Boysen, D.M. Mock. In HepG2 cells, coexisting carnitine deficiency masks important indicators of marginal biotin deficiency J Nutr. 145:32-40, 2015. PMCID: 4264022. |Abstract|
Kuruvilla D.J., J.A. Widness, D. Nalbant, R.L. Schmidt, D.M. Mock, P. Veng-Pedersen. A method to evaluate fetal erythropoiesis from postnatal survival of fetal RBCs. AAPS J. 17:1246- 1254, 2015. |Abstract|
Mock D.M., J.A. Widness, P. Veng-Pedersen, R.G. Strauss, J.A. Cancelas, R.M. Cohen, C.J. Lindsell, R.S. Franco. Measurement of post-transfusion red cell survival with the biotin label. Transfusion Medicine Reviews 28:114-125, 2014. PMCID: PMC4122272. |Abstract|
Mock, D.M.: Biotin In: Modern Nutrition in Health and Disease. 11th Ed, Ross, A.C.; Caballero, B.; Cousins, R.J.; Tucker, K.L.; Ziegler T.R. Lippincott Williams & Wilkens, Baltimore, 2014. p 390-398.
Widness JA, Nalbant D, Matthews NI, Strauss RG, Schmidt RL, Cress GA, Zimmerman MB, and Mock DM. Tracking Donor RBC Survival in Premature Infants: Agreement of Multiple Populations of Biotin Labeled RBCs with Kidd Antigen Mismatched RBCs Pediatr Res. 74:689-697, 2013. PMCID: PMC3913052. |Abstract|
Nalbant D., P. Bhandary, N.I. Matthews. R.L. Schmidt, A. Bogusiewicz, G.A. Cress, M.B. Zimmerman, R.G. Strauss, D.M. Mock, J.A. Widness. Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion. Pediatr Res. 74:592-600, 2013. PMCID: PMC3907947. |Abstract|
Bogusiewicz, A., T.D. Horvath, S.L. Stratton, D.M. Mock, G. Boysen. Measurement of acylcarnitines substrate to product ratios specific to biotin-dependent carboxylases offers a combination of indicators of biotin status in humans. J Nutr 142(9):1621-5, 2012 PMID: 22833654, PMCID: 3417829 |Abstract|
Stratton, S.L., C.L. Henrich, N.I. Matthews, A. Bogusiewicz, A.M. Dawson, T.D. Horvath, J.H. Moran, G. Boysen, D.M. Mock. Marginal Biotin Deficiency Can be Induced Experimentally in Humans using a Cost-Effective Outpatient Design. J Nutr 142(1):22-6, 2012. PMID: 22157538, PMCID: 3237229 |Abstract|