Professor and Vice Chair

Ph.D., University of Portsmouth, UK

E-mailChambersTimothyC@uams.edu
Office:  (501)686-5755 – Biomedical Research Center B405F
Lab:  (501)686-5756 – Biomedical Research Center B403, B404
FAX:  (501)686-8169

Cytotoxic signaling mechanisms of anticancer drugs

Our laboratory is interested in basic aspects of cancer chemotherapy, especially the mechanisms that link drug-induced damage to destructive or protective cellular responses.  Our focus has been on understanding the role of Bcl-2 proteins in the mechanism of action of microtubule inhibitors and other anti-mitotic drugs.

 

Selected Publications

Alford, S.E., Kothari, A., Loeff, F.C., Eichhorn, J.M., Sakurikar, N., Goselink, H.M., Saylors, R.L., Jedema, I., Falkenburg, J.H., Chambers, T.C. (2015) BH3 Inhibitor Sensitivity and Bcl-2 Dependence in Primary Acute Lymphoblastic Leukemia Cells. Cancer Res. 75(7):1366-75. |Abstract|

Eichhorn, J.M., Kothari, A., and Chambers, T.C. (2014) Cyclin B1 overexpression induces cell death independent of mitotic arrest.  PLOS One. 9, e113283. |Abstract|

Eichhorn, J.M., Alford, S.E., Sakurikar, N., and Chambers, T.C. (2014). Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival. Exp Cell Res. 322, 415-424. |Abstract|

Sakurikar, N., Eichhorn, J.M., Alford, S.E., and Chambers, T.C. (2014). Identification of a mitotic death signature in cancer cell lines. Cancer Lett. 343, 232-238. |Abstract|

Eichhorn, J.M., Alford, S.E., Hughes, C.C., Fenical, W., and Chambers, T.C. (2013). Purported Mcl-1 inhibitor marinopyrrole A fails to show selective cytotoxicity for Mcl-1-dependent cell lines. Cell Death Dis. 4, e880. |Abstract|

Eichhorn, J.M., Sakurikar, N., Alford, S.E., Chu, R., and Chambers, T.C. (2013). Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death. Cell Death Dis. 4, e834. |Abstract|

Sakurikar, N., Eichhorn, J.M., and Chambers, T.C. (2012). Cyclin-dependent kinase-1 (Cdk1)/cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. J Biol Chem. 287, 39193-39204. |Abstract|

Terrano, D.T., Upreti, M., and Chambers, T.C.  (2010) Cyclin-dependent kinase 1-mediated BcL-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis. Molecular and Cellular Biology.  30, 640-656. |Abstract|